@charset "UTF-8";
/*
*ローディングアニメーション 
*/
.loader {
  position: fixed;
  width: 100%;
  height: 100%;
  background: #fff;
  display: flex;
  align-items: center;
  justify-content: center;
  flex-direction: column;
  z-index: 9999;
}

.logo {
	opacity: 0;
	transition: opacity 1s ease;
	position: relative;
	margin: 10px 0;
}

.logo1 {
	width: 250px;
}

/* 表示アニメーション */
.logo1.fade-in {
  opacity: 1;
}

.logo1.slide-up {
  animation: slideUp 0.4s ease forwards;
}

@keyframes slideUp {
  0% { transform: translateY(0); }
  100% { transform: translateY(-40px); }
}

.logo2.fade-in {
  opacity: 1;
  transform: scale(1);
  transition: opacity 1s ease, transform 1s ease;
}

/* メインコンテンツは非表示にしておく */
.container {
  opacity: 0;
  transition: opacity 1s ease;
}
.home {
	width: 100%;
}
/*
* 立ち上がりフェードインの記載
*/
/*フェードアニメーション*/
.open-fade-up {
	opacity: 0;
	transform: translateY(20px);
	animation: fadeInUP 1s ease forwards;
}
.open-fade-right {
	opacity: 0;
	transform: translateX(30px);
	animation: fadeInRight 1s ease forwards;
}
.open-fade-left {
	opacity: 0;
	transform: translateX(-30px);
	animation: fadeInLeft 1s ease forwards;
}
.open-fade-in {
	opacity: 0;
	animation: fadeIn 1s ease forwards;
}
.delay-1 {
	animation-delay: 0.3s;
}
.delay-2 {
	animation-delay: 0.8s;
}
.delay-3 {
	animation-delay: 1.3s;
}
.delay-4 {
	animation-delay: 1.8s;
}
.delay-5 {
	animation-delay: 2.3s;
}

@keyframes fadeInUP {
  to {
    opacity: 1;
    transform: translateY(0);
  }
}
@keyframes fadeInRight {
  to {
    opacity: 1;
    transform: translateX(0);
  }
}
@keyframes fadeInLeft {
  to {
    opacity: 1;
    transform: translateX(0);
  }
}
@keyframes fadeIn {
  to {
    opacity: 1;
  }
}
/*
 * メインビジュアル-スライダー
*/

.slide-media,.thumb-media {
	 position: relative;
	 overflow: hidden;
}
.slide-media img,.thumb-media img {
	position: absolute;
	top: 0;
    left: 0;
    width: 100%;
    height: 100%;
    -o-object-fit: cover;
       object-fit: cover;
}
.swiper-button-prev,.swiper-button-next {
	display: grid;
    place-content: center;
    width: 6.4rem;
    height: 6.4rem;
    cursor: pointer;
    -webkit-transition: var(--transition);
    transition: var(--transition);
}
.swiper-button-prev::before, .swiper-button-next::before {
	position: absolute;
    top: 0;
    right: 0;
    bottom: 0;
    left: 0;
    content: "";
    border-radius: 50%;
    -webkit-box-shadow: var(--box-shadow);
            box-shadow: var(--box-shadow);
}
.swiper-button-prev::after, .swiper-button-next::after {
	width: 1.2rem;
    height: 1.2rem;
    content: "";
    border: solid var(--color-gray);
    border-width: 3px 3px 0 0;
}
.swiper-button-prev::after {
	margin-left: 0.4rem;
    -webkit-transform: rotate(-135deg);
            transform: rotate(-135deg);
}
.swiper-button-next::after {
	margin-right: 0.4rem;
    -webkit-transform: rotate(45deg);
            transform: rotate(45deg);
}
.swiper-button-disabled {
    pointer-events: none;
	opacity: 0;
}
.visual {
	margin-bottom: 0;
}
.visual .l-inner {
    padding-bottom: 0;
}
.visual .swiper-fade .swiper-slide {
    -webkit-transition-property: opacity, -webkit-transform !important;
    transition-property: opacity, -webkit-transform !important;
    transition-property: opacity, transform !important;
    transition-property: opacity, transform, -webkit-transform !important;
    pointer-events: none;
}
.visual .swiper-fade .swiper-slide-active {
    pointer-events: auto;
}
.visual .swiper-pagination {
    position: absolute;
    z-index: 1;
    top: 0;
    bottom: 0;
    left: 3.2rem;
    height: -webkit-max-content;
    height: -moz-max-content;
    height: max-content;
    margin: auto;
}
.visual .swiper-pagination-bullet {
    display: block;
    width: 3px;
    height: 4rem;
    cursor: pointer;
    -webkit-transition: var(--transition);
    transition: var(--transition);
    background-color: rgba(255, 255, 255, 0.4);
  }
  .visual .swiper-pagination-bullet:not(:first-child) {
    margin-top: 0.8rem;
  }
  .visual .swiper-pagination-bullet-active {
    background-color: var(--color-theme);
  }
  .visual .slide-media {
    height: 800px;
  }
  .visual .slide-media img {
    -webkit-transition: 5s 1s ease-out;
    transition: 5s 1s ease-out;
  }
.visual .slide-title {
	width: 100%;
	display:flex;
	justify-content:flex-end;
	padding: 2rem 2.5rem;
	font-size:1.3rem;
	font-weight: normal;
	line-height: 1.6;
	position: absolute;
	right: 0%;
	bottom: 0%;
	margin-left: 16rem;
	color: #fff;
	backdrop-filter: blur(1px);
	letter-spacing: 0.05em;
	background: #ACCD02;
	background: linear-gradient(180deg,rgba(172, 205, 2, 0.16) 0%, rgba(122, 160, 1, 0.16) 100%);
}
.visual .slide-title span {
	display:block;
	margin-top: 20px;
	font-size:1.1rem;
	letter-spacing: 0;
}
.visual .swiper-slide[class*=-active] .slide-media img {
    -webkit-transition-delay: 0s;
            transition-delay: 0s;
    -webkit-transform: scale(1.05);
            transform: scale(1.05);
}
.visual .swiper-slide[class*=-active] .slide-title {
    -webkit-animation: mv01-fadeIn 2s 0.5s var(--easing) both;
            animation: mv01-fadeIn 2s 0.5s var(--easing) both;
}
@-webkit-keyframes mv01-fadeIn {
	0% {
		-webkit-transform: scale(0.5);
		        transform: scale(0.5);
		opacity: 0;
		-webkit-filter: blur(300px);
		        filter: blur(300px);
	}
	100% {
      -webkit-transform: scale(1);
	          transform: scale(1);
      opacity: 1;
      -webkit-filter: blur(0);
              filter: blur(0);
	}
}
@keyframes mv01-fadeIn {
	0% {
      -webkit-transform: scale(0.5);
              transform: scale(0.5);
      opacity: 0;
      -webkit-filter: blur(300px);
              filter: blur(300px);
    }
    100% {
      -webkit-transform: scale(1);
              transform: scale(1);
      opacity: 1;
      -webkit-filter: blur(0);
              filter: blur(0);
	}
}
.content_wrap {
	width: 100%;
	max-width: 1000px;
	margin: 0 auto;
	display:flex;
	justify-content:space-between;
}
/*お知らせ*/

.bg_section1{
	position:relative;
	width:100%;
}
.bg_section1::before {
	position:absolute;
	content:"";
	width: 100%;
	max-width:1300px;
	height: 100%;
	top:0;
	left:50%;
	transform: translateX(-70%);
	background-image: url("../images/common/bg.png");
	background-repeat: no-repeat;
	background-size:600px 600px;
	background-position: left 200px;
	opacity:0.6;
	z-index:-2;
	pointer-events: none;
}
.information {
	margin: 0 auto;
	padding: 70px 10px;
}
.information .content_title {
	width:20%;
}
.information .content_title .title_wrap h3{
	font-weight:400;
	line-height:2;
	position:relative;
	z-index:1;
}
.information .content_title .title_wrap h3 span {
	display:block;
	font-size:1.6em;
	letter-spacing:0.1em;
	line-height:1;
}
.information .content_title .title_wrap h3::before {
	position:absolute;
	top: 10%;
	left:-15%;
	content: "";
	width:57px;
	height:57px;
	background:#FFE1A7;
	border-radius:50%;
	z-index:-1;
}
.information .content {
	width:80%;
}
.information .content li {
	font-size:16px;
	display:flex;
	line-height:2;
}
.information .content .infotitle {
	padding-left: 2rem;
}
/*DIPG情報サイトについて*/
.about {
	padding: 80px 0;
}
.about .content_wrap {
	background:#fff;
	border-radius: 250px 0 0 250px;
	align-items: center;
	padding:2rem 0 2rem 6rem;
}
.about .content_title {
	width: 42%;
}
.about .content {
	width: 55%;
	padding:1rem 0.5rem 1rem 1rem;
}
.about .content_title .title_wrap{
	margin-bottom: 30px;
	padding-left:26px;
}
.about .content_title .title_wrap h3{
	font-weight:400;
	font-size:1.2em;
	line-height:1.5;
	position:relative;
	z-index:1;
}
.about .content_title .title_wrap h3 span {
	display:block;
	font-size:1em;
	letter-spacing:0.1em;
	line-height:1;
}
.about .content_title .title_wrap h3::before {
	position:absolute;
	top: -1%;
	left: -8%;
	content: "";
	width:57px;
	height:57px;
	background:#A7D3FF;
	border-radius:50%;
	z-index:-1;
}
.about .content_title .text {
	line-height: 1.5;
	margin-bottom:30px;
}
.btn_more {
	text-align:right;
	padding-right:2rem;
	font-size:16px;
}
.btn_more .submit a {
	position:relative;
	text-decoration:none;
	color:#14126E;
	transition: 0.5s;
}
.btn_more .submit a::after {
	content: '';
    position: absolute;
    right: -20px;
    top: 4px;
    width: 6px;
    height: 6px;
    border-top: 2px solid #14126E;
    border-right: 2px solid #14126E;
    transform: rotate(45deg);
    transition: 0.5s;
}
.btn_more .submit a:hover::after {
	right:-30px;
	border-top: 2px solid rgba(15, 58, 97, 0.69);
    border-right: 2px solid rgba(15, 58, 97, 0.69);
}
.btn_more .submit a:hover {
	color:rgba(15, 58, 97, 0.69);
}
.image img{
	border-radius: 20px;
}
/*DIPG-2023研究について*/
.bg_section2 {
	position:relative;
	overflow: hidden;
}
.bg_section2::before {
	position:absolute;
	content:"";
	width:100%;
	max-width: 1300px;
	height: 100%;
	top:0;
	right:50%;
	transform: translateX(70%);
	background-image: url("../images/common/bg.png");
	background-repeat: no-repeat;
	background-size:600px 600px;
	background-position: right 300px;
	opacity:0.6;
	z-index:-2;
	pointer-events: none;
}
.research {
	padding: 80px 0;
}
.research .content_wrap {
	background:#fff;
	border-radius: 0 250px 250px 0;
	align-items: center;
	padding:2rem 6rem 2rem 0;
}
.research .content_title {
	width: 42%;
}
.research .content {
	width: 55%;
	padding:1rem 0.5rem 1rem 1rem;
}
.research .content_title .title_wrap{
	margin-bottom: 30px;
}
.research .content_title .title_wrap h3{
	font-weight:400;
	font-size:1.2em;
	line-height:1.5;
	position:relative;
	z-index:1;
	border-bottom: solid 1px #000;
}
.research .content_title .text {
	line-height: 1.5;
	margin-bottom:30px;
}

/*DIPG疾患について-患者ご家族さまへ*/
.disease {
	padding: 80px 0;
}
.disease .content_wrap {
	justify-content:center;
	align-items:center;
}
.disease .content_wrap > div {
	width: 50%;
	aspect-ratio: 1 / 1.05;
	background-size:cover;
	transition: transform 0.5s ease;
}
.disease .content_wrap .dipg {
	background-image:url("../images/index/img_.top_dipg.png");
	background-repeat:no-repeat;
	border-radius: 250px 0 0 250px;
}
.disease .content_wrap .patient {
	background-image:url("../images/index/img_.top_patient.png");
	background-repeat:no-repeat;
	border-radius: 0 250px 250px 0;
}
.disease .content_wrap > div:hover {
	
}
.disease .content_wrap > div > div {
	position:relative;
	height:100%;
	overflow: hidden;
}
.disease .content_wrap .bg_dipg::before {
	position:absolute;
	top: 0;
	left: 0;
	z-index: 0;
	content: "";
	width: 100%;
	aspect-ratio: 1 / 1.05;
	border-radius: 250px 0 0 250px;
	background: #25A8C9;
	background: linear-gradient(180deg,rgba(37, 168, 201, 1) 0%, rgba(34, 133, 220, 1) 100%);
	opacity:0.6;
	transition: 0.5s;
}
.disease .content_wrap .bg_patient::before {
	position:absolute;
	top: 0;
	left: 0;
	z-index: 0;
	content: "";
	width: 100%;
	aspect-ratio: 1 / 1.05;
	border-radius: 0 250px 250px 0;
	background: #ACCD02;
	background: linear-gradient(180deg,rgba(172, 205, 2, 1) 0%, rgba(122, 160, 1, 1) 100%);
	opacity:0.6;
	transition: 0.5s;
}
.disease .content_wrap .bg_dipg:hover::before {
	opacity:0.15;
}
.disease .content_wrap .bg_patient:hover::before {
	opacity:0.15;
}
.disease .content_wrap > div > div a {
	display:flex;
	justify-content:center;
	align-items:center;
	position:relative;
	width:100%;
	height:100%;
	color:#fff;
	text-decoration:none;
	z-index:1;
}
.disease .content_wrap > div > div a h4 {
	font-size:20px;
}

/*メンバー*/
.member {
	padding: 70px 0;
}
.member .content_wrap {
	display:block;
}
.member .content_title {
	margin-bottom:100px;
}
.member .content_title h3 {
	font-weight:400;
	font-size:1.2em;
	line-height:1.5;
	position:relative;
	z-index:1;
}
.member .content_title h3 span {
	display:block;
	font-size:1em;
	letter-spacing:0.1em;
	line-height:1;
}
.member .content_title h3::before {
	position:absolute;
	top: 10%;
	left: -3%;
	content: "";
	width:57px;
	height:57px;
	background:#CCE0BD;
	border-radius:50%;
	z-index:-1;
}
.member .member_wrap {
	width:100%;
	padding: 30px 0 50px;
	display:flex;
	justify-content:space-between;
	align-items:center;
}
.member .member_wrap > div {
	position:relative;
	width:30%;
	display:flex;
	justify-content:space-between;
	align-items:flex-start;
}
.member .member_wrap > div::before {
	position:absolute;
	top:-60%;
	left:0;
	content:"";
	width:105%;
	aspect-ratio: 1 / 1;
	background:#F7F7F7;
	border-radius:50%;
	z-index:-1;
	pointer-events: none;
}
.member .member_wrap .text {
	width: calc( 100% - 150px );
	font-size: 14px;
}
.member .member_wrap .text h4{
	text-align:center;
	margin-bottom:2rem;
}
.member .member_wrap .text p {
	font-size:0.95em;
	line-height:1.2;
	padding-left: 2rem;
}
.member .member_wrap .text p.name {
	font-size:1rem;
	margin-bottom:10px;
}

.member .member_wrap .image {
	border-radius:0;
	width:150px;
	aspect-ratio: 1 / 1.05;
	background-size:cover;
	background-repeat:no-repeat;
}
.member .member_wrap .image.dr01 {
	background-image: url("../images/index/drsuzuki.png");
}
.member .member_wrap .image.dr02 {
	background-image: url("../images/index/drniduma.png");
}
.member .member_wrap .image.dr03 {
	background-image: url("../images/index/drchiba.png");
}
.member .btn_more {
	margin: 50px 0;
	text-align:center;
}

@media only screen and (max-width: 1024px) {
	html {
		-webkit-text-size-adjust: 100%;
	}
	.l-inner {
		padding: 0 4rem;
	}
	.pc {
		display: none !important;
	}
	.mv01 {
		
	}
	.mv01 .slide-media {
		height: max(70vh, 70vw);
	}
	.member .content_title {
		display:flex;
		justify-content:center;
	}
}
@media only screen and (max-width: 999px) {
	.member .member_wrap {
		flex-flow: column;
	}
	.member .member_wrap > div {
		width:310px;
		margin-bottom: 200px;
	}
	.member .member_wrap > div:last-child {
		margin-bottom:50px;
	}
}
@media only screen and (max-width: 750px) {
	.visual .slide-title {
		font-size:1.1rem;
		padding: 1rem 1.5rem;
	}
	.information .content_wrap  {
		flex-flow:column;
		align-items: center;
	}
	.information .content_title {
		margin-bottom:30px;
	}
	.information .content li {
		flex-flow:column;
		border-bottom: dotted 1px #909090;
		padding-bottom:10px;
		margin-bottom: 10px;
	}
	.information .content .infotitle {
		padding-left: 0;
	}
	.about .content_wrap {
		flex-flow:column-reverse;
		padding: 2rem 0;
	}
	.about .content {
		width: 80%;
	}
	.about .content_title {
		width:80%;
	}
	.research .content_wrap {
		flex-flow:column;
		padding: 2rem 0;
	}
	.research .content {
		width: 80%;
	}
	.research .content_title {
		width: 80%;
	}
}
@media only screen and (max-width: 599px) {
	html {
		
	}
	.pc-tab {
		display: none !important;
	}
	.visual .slide-title {
		font-size: 1rem;
		
	}
}
@media only screen and (min-width: 1025px) {
	.tab-sp {
		display: none !important;
	}
	.swiper-button-prev::before, .swiper-button-next::before {
		-webkit-transition: var(--transition);
		        transition: var(--transition);
	}
	.swiper-button-prev:hover::before, .swiper-button-next:hover::before {
		-webkit-transform: scale(1.2);
		        transform: scale(1.2);
	}
}
@media only screen and (min-width: 600px) {
	.sp {
		display: none !important;
	}
}

.member {
	padding: 70px 0;
}
.member .content_wrap {
	
}


@media screen and (max-width: 999px) {
	.member_wrap > div {
		width: 32%;
	}
	.member_wrap img {
		margin: 10% 5% 5%;
		width: 90%;
	}
	.member_wrap .text {
		margin: 0 5%;
		padding: 10px 5px;
	}
	.registry .content > .flex_wrap {
		flex-flow: column;
	}
	.registry .content_left {
		width: 100%;
		margin-bottom: 30px;
	}
	.registry h3 {
		text-align: center;
	}
	.registry .content_right {
		width: 100%;
		border-left: none;
	}
}
@media screen and (max-width: 750px) {
	.member .flex_wrap {
		flex-flow: column;
	}
}
@media screen and (max-width: 680px) {
	.research h2 {
		font-size: 26px;
	}
	.member_wrap {
		flex-flow: column;
	}
	.member_wrap > div {
		width: 100%;
		margin-bottom: 50px;
	}
	.member_wrap h3 {
		font-size:26px;
	}
	.member_wrap img {
		margin: 5%;
	}
	.registry .content_right .flex_wrap {
		flex-flow: column;
	}
	.registry .content_right .img {
		width: 100%;
	}
	.registry .content_right .text {
		width: 100%;
	}
	.registry .content_right .text p {
		text-align:center;
	}
}
@media screen and (max-width: 480px) {
	
}