@charset "UTF-8";

.content_header {
	width:100%;
	height:400px;
	background-size:cover;
	background-position:center bottom;
	background-repeat:no-repeat;
}
.content_hd_wrap {
	width:100%;
	height:100%;
	max-width:1000px;
	margin: 0 auto;
	display:flex;
	justify-content:flex-start;
	align-items:center;
	color:#fff;
}
.hd_text {
	padding:0 3rem;
	display:flex;
	align-items:center;
	flex-flow:column;
}
.hd_text h2 {
	font-size:24px;
	border-bottom:solid 1px #fff;
	padding:0.5rem 1rem;
}
.hd_text p {
	font-size:32px;
	font-family: "arial", sans-serif;
	font-weight:600;
	padding:0.5rem 0;
}
.hd_text h2 span {
	display:block;
}
.wrap {
	position:relative;
	background-image: url(../images/low/bg_main.png);
	background-repeat:repeat-y;
	/*background-size:contain;*/
	background-position:center top;
}
.wrap::before {
	position:absolute;
	top:0;
	left:0;
	width:100%;
	height:100%;
	content:"";
	/*background-image: url(../images/low/bg_main.png);
	background-repeat:repeat-y;
	background-size:contain;
	background-position:center top;*/
	z-index:-1;
}
.container {
	padding:80px 0;
}
.content_wrap{
	width: 100%;
	max-width:1000px;
	margin: 0 auto;
	background:rgb(255,255,255,0.7);
	backdrop-filter: blur(3px);
}
.center {
	text-align: center;
}
section {
	
}
.content {
	padding-bottom:50px;
}
h3 {
	text-align:center;
	font-size:24px;
	margin: 50px auto 80px;
	position:relative;
}
h3 span {
	position:relative;
	padding: 0.25em 1rem;
	z-index:1;
}
h3 span::before {
	position:absolute;
	content:"";
	bottom:0;
	left:0;
	width:100%;
	height:50%;
	z-index:-1;
}
h4 {
	font-size:20px;
	color:#3F8BD6;
	border-bottom:solid 2px #000;
	padding:0 0 5px 5px;
	margin:20px 0 20px;
}
h4 span {
	color:#000;
}
p.text {
	padding-left:5px;
	line-height:1.5;
	font-size:18px;
}
.content_header{
	background-image:url(../images/low/diagnosis/bg_hd_diagnosis.png);
}
/*
 *ABOUT DIPG疾患について
*/
.about .content_header{
	background-image:url(../images/low/bg_hd_reference.png);
}

.about .hd_text {
	background: #A7D3FF;
	background: linear-gradient(90deg,rgba(167, 211, 255, 1) 0%, rgba(124, 174, 245, 1) 100%);
}
.about h3 span::before {
	background-color:#A7D3FF;
}
.about .introduction {
	background: #EAF4FD;
	border-radius:16px;
	padding:2rem;
}
.about .introduction h3 {
	text-align:left;
	margin:0 0 30px 0;
}
.about .introduction > p {
	font-size:20px;
	line-height:1.5;
}
.about .main_text h3 {
	text-align:center;
	color:#3F8BD6;
	background:#EAF4FD;
	padding: 1rem 1rem;
	border-radius:16px;
	margin:50px 10%;
	position:relative;
}
.about .main_text h3 span {
	line-height:2;
	position:relative;
}
.about .main_text h3 span::before {
	height:100%;
	background:#EAF4FD;
	border-radius:16px;
}
.about .main_text h3::after {
	content:"";
	position:absolute;
	top:100%;
	left:50%;
	margin-left: -15px;
	border: 15px solid transparent;
	border-top: 15px solid #EAF4FD;
}

.about .content img {
	width: 45px;
	padding-right: 10px;
}
.about .content ul li {
	font-size: 18px;
	line-height: 1.5;
	margin-bottom: 10px;
	padding-left: 20px;
	position:relative;
}
.about .content ul li::before {
	position: absolute;
	content: "";
	top: 9px;
	left: 0;
	width: 10px;
	height: 10px;
	background: #3F8BD6;
	border-radius: 50%;
}
.about .annotation {
	background: #EAF4FD;
    border-radius: 16px;
    padding: 2rem;
	margin: 30px 0 ;
}
.about .annotation li {
	line-height:2;
	font-size: 16px;
	color: rgba(15, 58, 97, 1);
}

/*
 *diagnosis DIPGと診断されたら
*/
.diagnosis .content_header{
	background-image:url(../images/low/diagnosis/bg_hd_diagnosis.png);
}
.diagnosis .hd_text {
	background: #A7D3FF;
	background: linear-gradient(90deg,rgba(167, 211, 255, 1) 0%, rgba(124, 174, 245, 1) 100%);
}
.diagnosis h3 span::before {
	background-color:#A7D3FF;
}
.diagnosis .understanding h3,.diagnosis .practical h3 {
	color:#3F8BD6;
}
.diagnosis .understanding h3 span,.diagnosis .practical h3 span {
	padding: 1rem 5rem;
}
.diagnosis .understanding h3 span::before,.diagnosis .practical h3 span::before {
	height:100%;
	background:#EAF4FD;
	border-radius:16px;
}
.diagnosis .understanding h3 span::after,.diagnosis .practical h3 span::after {
	content:"";
	position:absolute;
	top:100%;
	left:50%;
	margin-left: -15px;
	border: 15px solid transparent;
	border-top: 15px solid #EAF4FD;
}

.diagnosis .flex_wrap{
	display:flex;
	justify-content:space-between;
	width: 100%;
	background:#EAF4FD;
	border-radius:16px;
	padding: 3rem 2rem 2rem;
}
.diagnosis .flex_wrap > div {
	width: 50%;
	font-size:16px;
}
.diagnosis .understanding .left_col {
	padding: 0 2%;
	border-right: solid 2px #fff;
}
.diagnosis .understanding .right_col {
	padding: 0 2%;
}
.diagnosis .understanding .box {
	padding: 0px 0px 0 0px;
}

.diagnosis .understanding .sumit_btn {
	margin: 30px 0;
}
.diagnosis .understanding .sumit_btn p {
	font-size: 16px;
	font-weight:600;
	display: flex;
	justify-content:center;
	align-items: center;
	width: 100%;
	height: auto;
}
.diagnosis .understanding .sumit_btn a {
	display: block;
	width: 100%;
	color:#FFF;
	text-decoration:none;
	transition: 0.5s;
	background:#50A5FA;
	padding: 20px 0;
	text-align: center;
	border:solid 2px #50A5FA;
}
.diagnosis .understanding .sumit_btn a i {
	padding-right:20px;
}
.diagnosis .understanding .sumit_btn a:hover {
	background: #fff;
	color:  #50A5FA;
}


.diagnosis .practical {
	
}
.diagnosis .practical .center {
	font-size: 20px;
	margin-bottom:50px;
}


.diagnosis .practical ol {
	padding: 0 1rem;
}
.diagnosis .practical ol li {
	counter-increment: cnt;
	font-size: 20px;
	line-height:1.5;
}
.diagnosis .practical ol li::before {
	content: "("counter(cnt)")";
}
.diagnosis .practical .flex_box {
	margin:30px 0;
	display: flex;
	flex-flow:column;
	justify-content: space-between;
	align-items: flex-end;
}
.diagnosis .flex_box .image,.diagnosis .flex_box .text {
	width: 100%;
}
.diagnosis .flex_box .url {
	margin:50px 0;
	width: 100%;
	padding: 2rem 0;
	background:#EAF4FD;
	border-radius:16px;
}
.diagnosis .flex_box .url a {
	text-decoration:none;
	font-size:20px;
	color:#fff;
	background:#50A5FA;
	border: solid 2px #50A5FA;
	padding: 0.5rem 3rem;
	transition: 0.5s;
}
.diagnosis .flex_box .url a:hover {
	background:#fff;
	color:#50A5FA;
}
.diagnosis .flex_box .url p {
	font-size: 16px;
	text-align: center;
}
.diagnosis .flex_box .url p i {
	padding-right:20px;
}
.diagnosis .practical .notes {
	padding: 1rem 1rem;
	font-size: 16px;
	line-height: 2;
}
.diagnosis .practical h5 {
	font-weight: 400;
}
.diagnosis .merit {
	background:#EAF4FD;
	border-radius:16px;
	padding:2rem;
}
.diagnosis .merit h5 {
	margin-bottom:20px;
	font-weight:600;
}
.diagnosis .merit p {
	font-weight:300;
	line-height:1.5;
}
}
/*
 *  practical 社会資源の活用
*/
.practical {
	
}
.practical ol li {
	line-height:1.5;
	font-size:18px;
}

.practical ol {
	counter-reset: list-counter;
	list-style: none;
	padding-left: 0;
	margin-bottom:20px;
}
.practical ol li {
	counter-increment: list-counter;
	position: relative;
	padding-left: 1em;
}
.practical ol li::before {
  content: counter(list-counter) ". ";
  position: absolute;
  left: 0;
  color: #A7D3FF;
  font-weight: bold;
}
.practical .notes {
	padding:10px;
	line-height:1.2;
}
/*
 * reference 参考文献
*/
.reference {
	
}

.reference .content_header{
	background-image:url(../images/low/bg_hd_reference.png);
}
.reference .hd_text {
	background: #A7D3FF;
	background: linear-gradient(90deg,rgba(167, 211, 255, 1) 0%, rgba(124, 174, 245, 1) 100%);
}
.reference h3 span::before {
	background-color:#A7D3FF;
}
.reference .content li {
	font-size:18px;
	line-height: 1.5;
	border-bottom: solid 1px #3F8BD6;
	padding: 2rem 1rem;
}
.reference .content li .title {
	color: #3F8BD6;
	font-weight:600;
	margin-bottom:0.5rem;
}
/*
 * research DIPG-2023のご紹介
*/
.research .content_header{
	background-image:url(../images/low/bg_hd_facility.png);
}


.research .hd_text {
	background: #A7D3FF;
	background: linear-gradient(90deg,rgba(167, 211, 255, 1) 0%, rgba(124, 174, 245, 1) 100%);
}
.research h3 span::before {
	background-color:#A7D3FF;
}
.research .introduction {
	background: #EAF4FD;
	border-radius:16px;
	padding:2rem;
}
.research .introduction h3 {
	text-align:center;
	line-height:1.5;
	margin:0 0 30px 0;
}
.research .introduction .text {
	text-align:center;
	font-size:20px;
	line-height:1.5;
}
.research .introduction .text span {
	color:#FF0000;
}

.research .purpose .flex_box {
	display:flex;
	justify-content:space-between;
}
.research .purpose .flex_box div {
	width: 48%;
	background:#EAF4FD;
	border-radius:16px;
	padding:1rem;
}
.research .purpose .flex_box h5 {
	font-size: 18px;
    margin: 0px 0 25px;
	padding: 0 25px;
	color: #3F8BD6;
	text-align: center;
	position: relative;
}

.research .purpose p{
	font-size:16px;
	line-height: 1.5;
}
.research .purpose .bold {
	font-weight: 700;
	text-align:center;
	margin-bottom: 15px;
}
.research .overview {
	background:#F5F5F5;
	border-radius:16px;
	padding:1rem 2rem;
}
.research .overview h4 {
	color:#3F8BD6;
	border-bottom:solid 2px #fff;
}
.research .overview dl {
	display: flex;
	margin-bottom: 30px;
	font-size: 18px;
	line-height: 1.5;
	padding-left:5px;
}
.research .overview dl dt {
	width: 30%;
	color: #3F8BD6;
	font-weight: 600;
}
.research .overview dl dd {
	width: 70%;
}
.research .evaluation {
	padding: 50px 0;
}

.research .evaluation .text {
	font-size: 18px;
	line-height: 1.5;
}
.introduction .schedule .content_wrap {
	padding: 50px 3.5rem;
}
/*
 *memberメンバー紹介 
*/
.member .content {
	margin-top:150px;
}
.member .hd_text {
	background: #B5DEA0;
	background: linear-gradient(90deg,rgba(181, 222, 160, 1) 0%, rgba(120, 191, 103, 1) 100%);
}
.member h3 span::before {
	background-color:#CCE0BD;
}
.member_wrap {
	width: 100%;
    padding: 30px 0 50px;
    display: flex;
    justify-content: space-between;
    align-items: center;
}
.member .member_wrap > div {
	position:relative;
	width:30%;
	display:flex;
	justify-content:space-between;
	align-items:flex-start;
}
.member .member_wrap > div::before {
	position:absolute;
	top:-60%;
	left:0;
	content:"";
	width:105%;
	aspect-ratio: 1 / 1;
	background:#F7F7F7;
	border-radius:50%;
	z-index:-1;
	pointer-events: none;
}
.member .member_wrap .text {
	width: calc( 100% - 150px );
	font-size: 14px;
}
.member .member_wrap .text h4{
	text-align:center;
	margin-bottom:2rem;
	border-bottom:none;
	color:#000;
}
.member .member_wrap .text p {
	font-size:0.95em;
	line-height:1.2;
	padding-left: 2rem;
}
.member .member_wrap .text p.name {
	font-size:1rem;
	margin-bottom:10px;
}

.member .member_wrap .image {
	border-radius:0;
	width:150px;
	aspect-ratio: 1 / 1.05;
	background-size:cover;
	background-repeat:no-repeat;
}
.member .member_wrap .image.dr01 {
	background-image: url("../images/index/drsuzuki.png");
}
.member .member_wrap .image.dr02 {
	background-image: url("../images/index/drniduma.png");
}
.member .member_wrap .image.dr03 {
	background-image: url("../images/index/drchiba.png");
}

.member .member_list {
	
}
.member h4 {
	color:#429A3E;
}
.member .member_list p {
	padding-left: 5px;
    line-height: 1.5;
    font-size: 18px;
}
}
.member .member_list .committee p {
	
}
/*
 * DIPG-2023研究（医療従事者向け）
*/
/*
 * 施設登録までの流れ
*/
.how-to-participate {
	
}
.how-to-participate .flex_box {
	display:flex;
	justify-content:space-between;
}
.how-to-participate .hd_text {
	background: #B5DEA0;
	background: linear-gradient(90deg,rgba(181, 222, 160, 1) 0%, rgba(120, 191, 103, 1) 100%);
}
.how-to-participate h3 span::before {
	background-color:#CCE0BD;
}
.how-to-participate .text {
	font-size:18px;
	line-height: 1.5;
}
.how-to-participate h4 {
	color:#429A3E;
	border-bottom:none;	
	position:relative;
	padding-left:20px;
	margin:0;
}
.how-to-participate h4::before {
	position:absolute;
	top:2.5px;
	left:0;
	content:"";
	background:#429A3E;
	width:16px;
	height:16px;
	border-radius:50%;
}
.how-to-participate .regi_content {
	padding-left:3rem;
	margin-left:7px;
	border-left: solid 1px #959595;
	padding: 2rem 0 3rem 3rem;
}
.how-to-participate .content{
	padding-bottom:0;
}
.how-to-participate .registration {
	margin-bottom:50px;
}
.how-to-participate .facility_registration .text {
	padding: 30px 0;
}
.how-to-participate .text_area {
	padding:1rem;
	background:#E5F4DB;
	border-radius:16px;
}
.how-to-participate .facility_registration .text_area {
	line-height:1.5;
	font-size:18px;
}
.how-to-participate .facility_registration .text_area h5 {
	font-size:20px;
	margin-bottom:10px;
}
.how-to-participate .facility_registration .text_area ol {
	padding-left:5px;
}
.how-to-participate .facility_registration .text_area a {
	font-weight:600;
}
.how-to-participate .facility_registration .text_area p.email {
	padding:1rem 1rem 0 1rem;
}
.how-to-participate .redcap_registration .text_wrap {
	padding: 1rem 0;
	font-size:18px;
	line-height:1.5;
}
.how-to-participate .redcap_registration .text_wrap span {
	color:#D10000;
}
.how-to-participate .flex_box .submit_btn{
	width:48%;
	margin: 30px 0;
}
.how-to-participate .submit_btn p {
	font-size: 16px;
    font-weight: 600;
    display: flex;
    justify-content: center;
    align-items: center;
    width: 100%;
    height: auto;
}
.how-to-participate .submit_btn p a {
	display: block;
    width: 100%;
    color: #FFF;
    text-decoration: none;
    transition: 0.5s;
    background: #50A5FA;
    padding: 20px 0;
    text-align: center;
    border: solid 2px #50A5FA;
}
.how-to-participate .redcap_registration .flex_box .submit_btn i {
	font-size:1.2em;
	padding-right:20px;
}
.how-to-participate .submit_btn p a:hover {
    background: #fff;
    color: #50A5FA;
}
.how-to-participate .redcap_registration .flex_box .site_image {
	width:68%;
}
.how-to-participate .redcap_registration .flex_box .irb {
	width:30%;
}
.how-to-participate .redcap_registration .flex_box .irb h5 {
	text-align:center;
	font-size:20px;
	margin-bottom:20px;
}
.how-to-participate .completion .submit_btn{
	width:48%;
	margin: 30px auto;
}
/*
 * flow-of-registration 症例登録までの流れ
*/
.flow-of-registration .farst_registration{
	margin-top:50px;
}
.flow-of-registration .hd_text {
	background: #B5DEA0;
	background: linear-gradient(90deg,rgba(181, 222, 160, 1) 0%, rgba(120, 191, 103, 1) 100%);
}
.flow-of-registration h3 span::before {
	background-color:#CCE0BD;
}
.flow-of-registration .farst_registration h4,.flow-of-registration .second_registration h4 {
	color:#429A3E;
	border-bottom:none;	
	position:relative;
	padding-left:20px;
	margin:0;
}
.flow-of-registration .farst_registration h4::before,.flow-of-registration .second_registration h4::before {
	position:absolute;
	top:2.5px;
	left:0;
	content:"";
	background:#429A3E;
	width:16px;
	height:16px;
	border-radius:50%;
}

.flow-of-registration .regi_content {
	margin-left:7px;
	border-left: solid 1px #959595;
	padding: 2rem 0 3rem 3rem;
}
.flow-of-registration .second_registration .regi_content {
	border-left:none;
}
.flow-of-registration .content {
	padding-bottom:0;
}

.flow-of-registration .submit {
	margin: 50px auto 30px;
	width: 48%;
}
.flow-of-registration .submit p {
	font-size: 16px;
    font-weight: 600;
    display: flex;
    justify-content: center;
    align-items: center;
    width: 100%;
    height: auto;
}
.flow-of-registration .submit p a {
	display: block;
    width: 100%;
    color: #FFF;
    text-decoration: none;
    transition: 0.5s;
    background: #50A5FA;
    padding: 20px 0;
    text-align: center;
    border: solid 2px #50A5FA;
}
.flow-of-registration .submit p a:hover {
	background: #fff;
    color: #50A5FA;
}
.flow-of-registration .image_diagnosis {
	background:#F5F5F5;
	padding:1rem 2rem;
	border-radius:16px;
}
.flow-of-registration .image_diagnosis h4 {
	color:#429A3E;
	border-bottom:solid 2px #fff;
}
.flow-of-registration .image_diagnosis .text {
	padding-bottom:10px;
}
.flow-of-registration .image_diagnosis .text span {
	color: red;
}
.flow-of-registration .list {
	margin-top: 30px;
}
.flow-of-registration .list h4 {
	color:#429A3E;
}
.flow-of-registration .list ul li {
	font-size: 18px;
	line-height: 2;
	list-style:none;
	display:flex;
	align-items:center;
}
.flow-of-registration .list ul li div {
	width:85%;
}
.flow-of-registration .list ul li div.name {
	width:15%;
}

/*
 * proposal 研究計画書
*/

.proposal {
	
}
.proposal .content_header{
	background-image:url(../images/low/bg_hd_faq.png);
}
.proposal .hd_text {
	background: #B5DEA0;
	background: linear-gradient(90deg,rgba(181, 222, 160, 1) 0%, rgba(120, 191, 103, 1) 100%);
}
.proposal h3 span::before {
	background-color:#CCE0BD;
}
.proposal .content li {
	position:relative;
	border-bottom:solid 1px #429A3E;
	padding-left:30px;
	padding-bottom:1rem;
	margin-bottom:1rem;
	font-size:18px;
}
.proposal .content li::before {
	position:absolute;
	top:0;
	left:0;
	content:"";
	background: #429A3E;
	border: solid 2px #429A3E;
	width:11px;
	height:11px;
	border-radius:50%;
	transition: transform 0.3s ease;
}
.proposal .content li:hover::before {
	background: #fff;
}
.proposal .content li a {
	color: #429A3E;
	text-decoration: none;
	position:relative;
	padding-right:30px;
}
.proposal .content li a::after {
	position:absolute;
	font-family: "Font Awesome 6 Free";
	content:"\f061";
	font-weight: 900;
	top;3px;
	right:0;
	transition: transform 0.3s ease;
}
.proposal .content li a:hover::after {
	transform: translateX(10px); 
}

/*
 * case-registration-site 症例登録サイト
*/

.case-registration-site {
	
}
.case-registration-site .hd_text {
	background: #B5DEA0;
	background: linear-gradient(90deg,rgba(181, 222, 160, 1) 0%, rgba(120, 191, 103, 1) 100%);
}
.case-registration-site h3 span::before {
	background-color:#CCE0BD;
}
.case-registration-site .submit_area {
	display: flex;
	justify-content: space-between;
	align-items:center;
}
.case-registration-site .submit_area .submit {
	width: 48%;
}
.case-registration-site .submit_area .submit p{
	font-size: 16px;
    font-weight: 600;
    display: flex;
    justify-content: center;
    align-items: center;
    width: 100%;
	height: auto;
}
.case-registration-site .submit_area .submit a {
	display: block;
    width: 100%;
    color: #FFF;
    text-decoration: none;
    transition: 0.5s;
    background: #50A5FA;
    padding: 20px 0;
    text-align: center;
    border: solid 2px #50A5FA;
}
.case-registration-site .submit_area .submit a:hover {
	background: #fff;
    color: #50A5FA;
}
/*
 * FAQ
 */

.faq{
	
}
.faq .content_header{
	background-image:url(../images/low/bg_hd_faq.png);
}
.faq .hd_text {
	background: #B5DEA0;
	background: linear-gradient(90deg,rgba(181, 222, 160, 1) 0%, rgba(120, 191, 103, 1) 100%);
}
.faq h3 span::before {
	background-color:#CCE0BD;
}
.faq .content li {
	margin-top:30px;
}
.faq .title {
	display:flex;
	border-bottom: solid 2px #000;
	padding: 1rem;
}
.faq .title p {
	width:90%;
	color:#429A3E;
	font-size:18px;
	font-weight:600;
	line-height:1.5;
}
.faq .title > div,.faq .text > div {
	width: 60px;
}
.faq .title span {
	background:#429A3E;
	color:#fff;
	font-weight:600;
	padding:0.3rem 0.5rem;
	border-radius:16px;
	letter-spacing:0.1em;
	font-size:20px;
}
.faq .text {
	display:flex;
	padding: 1rem;
}
.faq .text span {
	background:#D63F3F;
	color:#fff;
	font-weight:600;
	padding:0.3rem 0.5rem;
	border-radius:16px;
	letter-spacing:0.1em;
	font-size:20px;
}
.faq .text p {
	width:90%;
	color:#000;
	font-size:18px;
	line-height:1.5;
}

/*
 * hospital 参加施設一覧
*/
.hospital .content_header{
	background-image:url(../images/low/bg_hd_facility.png);
}
.hospital .hd_text {
	background: #DBA02A;
	background: linear-gradient(270deg,rgba(219, 160, 42, 1) 0%, rgba(231, 199, 128, 1) 100%);
}
.hospital  h3 span::before {
	background-color:#F2DDB3;
}

.facilities section {
	padding-top: 30px;
}

.facilities .flex_box {
	display: flex;
	justify-content:space-between;
}
.facilities .flex_box div {
	width: 48%;
}
.facilities h4 {
	font-size: 20px;
	line-height: 1.5;
	text-align:center;
	margin-bottom: 20px;
	color:#959595;
	border-bottom: solid 2px #959595;
}
.facilities .practicable h4 {
	color:#DBA02A;
	border-bottom: solid 2px #DBA02A;
} 
.facilities li {
	font-size: 18px;
	line-height:1.5;
	margin-bottom: 20px;
	position:relative;
	padding-left:20px;
}
.facilities li::before {
	position:absolute;
	content: "";
	top: 10px;
	left: 0;
	width:8px;
	height:8px;
	border-radius:50%;
	background:#959595;
}
.facilities .practicable  li::before {
	background:#DBA02A;
}
.facilities .notes {
	font-size: 20px;
	text-align:center;
	margin-top: 50px;
	color: red;
	line-height: 1.5;
}


/*
 * patient患者・家族会
*/

.patient .content_header{
	background-image:url(../images/low/bg_hd_patient.png);
}

.patient .flex_box {
	display:flex;
}
.patient .hd_text {
	background: #E6B5E1;
	background: linear-gradient(90deg,rgba(230, 181, 225, 1) 0%, rgba(230, 181, 225, 1) 100%);
}
.patient h3 span::before {
	background-color:#F4C9EF;
}

.patient h4 {
	color:#000;
	border-bottom:none;
}
.patient .text {
	padding:1rem 2rem;
	font-size: 18px;
	line-height:1.5;
}
.patient .list {
	background:#FFEFFD;
	border-radius:16px;
	padding:2rem;
}
.patient .list li {
	border-bottom: solid 1px #B45D8C;
	padding-bottom:1rem;
	margin-bottom:1rem;
}
.patient .list h5 {
	font-weight:400;
	font-size:16px;
	margin-bottom:10px;
}
.patient .list .left_cont {
	width:75%;
}
.patient .list .image {
	width:25%;
}
.patient .list .image.japan {
	display:flex;
	justify-content:center;
}
.patient .list .image.japan img {
	width:18%;
}
/*
 * clinical-trial DIPGの臨床試験
*/
.clinical-trial .content_header{
	background-image:url(../images/low/bg_hd_clinical-trial.png);
}
.clinical-trial .hd_text {
	background: #A7D3FF;
	background: linear-gradient(90deg,rgba(167, 211, 255, 1) 0%, rgba(124, 174, 245, 1) 100%);
}
.clinical-trial h3 span::before {
	background-color:#A7D3FF;
}

.clinical-trial .flex_box > div {
	width:420px;
	height:300px;
	position:relative;
}
.clinical-trial .flex_box .clinical {
	background-image: url(../images/low/bg_clinical01.png);
	background-repeat:no-repeat;
}
.clinical-trial .flex_box .jrct{
	background-image: url(../images/low/bg_clinical02.png);
	background-repeat:no-repeat;
}
.clinical-trial .flex_box div a {
	color:#EDF6FF;
	font-size: 24px;
	display:block;
}
.clinical-trial .flex_box {
	display: flex;
	justify-content: space-around;
}

.clinical-trial .flex_box .background {
	position: absolute;
    right: 0;
    bottom: 0;
    width: 420px;
    height: 111px;
    display: flex;
    flex-flow: column;
    align-items: center;
    justify-content: center;
    background: #7CAEF5;
background: linear-gradient(0deg,rgba(124, 174, 245, 0.8) 0%, rgba(167, 211, 255, 0.8) 100%);
    transition: 0.3s;
}
.clinical-trial .flex_box a:hover .background {
	height:300px;
}
.clinical-trial .flex_box p {
	line-height:1.5;
	font-weight:500;
}
.clinical-trial .flex_box p span {
	font-size:18px;
	padding-left:5px;
}

/*
 * 在宅医療
 */
.healthcare_facility .content_header{
	background-image:url(../images/low/bg_hd_facility.png);
}
.healthcare_facility .hd_text {
	background: #DBA02A;
	background: linear-gradient(270deg,rgba(219, 160, 42, 1) 0%, rgba(231, 199, 128, 1) 100%);
}
.healthcare_facility h3 span::before {
	background-color:#F2DDB3;
}

.healthcare_facility .content {
	padding: 0 20px 50px;
}
.healthcare_facility .content p {
	margin: 30px auto;
	line-height:1.5;
}

.healthcare_facility .map a {
	color: inherit;
    text-decoration: none;
    -webkit-transition: all 0.5s;
    -moz-transition: all 0.5s;
    -o-transition: all 0.5s;
    transition: all 0.5s;
}
.healthcare_facility .map{
	position: relative;
	line-height: 0;
	background: rgba(230,230,255,0.3);
	border-radius: 5px;
}
.healthcare_facility .map .tabBtn {
	max-width: 1200px;
    width: 100%;
    height: 100%;
    position: absolute;
    top: 0;
    left: 0;
    right: 0;
    margin: auto;
}
.healthcare_facility .map .tabBtn .item {
	background: #fff;
    display: block;
    width: 5.3%;
    height: 7.1%;
    position: absolute;
    cursor: pointer;
    text-indent: -9999px;
    opacity: 0;
    border-radius: 4px;
}
.healthcare_facility .map .tabBtn .hokkaido{
	width: 11.4%;
    height: 15.5%;
    top: 5.2%;
    left: 84.6%;
}
.healthcare_facility .map .tabBtn .aomori {
	top: 21.8%;
    left: 84.6%;
}
.healthcare_facility .map .tabBtn .iwate {
	top: 30%;
    left: 90.7%;
}
.healthcare_facility .map .tabBtn .miyagi {
	top: 38.3%;
    left: 90.7%;
}
.healthcare_facility .map .tabBtn .akita {
	top: 30%;
    left: 84.6%;
}
.healthcare_facility .map .tabBtn .yamagata {
	top: 38.3%;
    left: 84.6%;
}
.healthcare_facility .map .tabBtn .fukushima {
	top: 46.6%;
    left: 90.7%;
}
.healthcare_facility .map .tabBtn .ibaraki {
	top: 54.8%;
    left: 90.7%;
}
.healthcare_facility .map .tabBtn .tochigi{
	top: 46.6%;
    left: 84.6%;
}
.healthcare_facility .map .tabBtn .gunma {
	top: 54.8%;
    left: 78.4%;
}
.healthcare_facility .map .tabBtn .saitama {
	top: 54.8%;
    left: 84.6%;
}
.healthcare_facility .map .tabBtn .chiba {
	top: 63.1%;
    left: 90.7%;
}
.healthcare_facility .map .tabBtn .tokyo {
	top: 63.1%;
    left: 84.6%;
}
.healthcare_facility .map .tabBtn .kanagawa {
	top: 63.1%;
    left: 78.4%;
}
.healthcare_facility .map .tabBtn .yamanashi {
	top: 63.1%;
    left: 72.1%;
}
.healthcare_facility .map .tabBtn .nagano {
	top: 54.8%;
    left: 72.1%;
}
.healthcare_facility .map .tabBtn .niigata {
	top: 46.6%;
    left: 78.4%;
}
.healthcare_facility .map .tabBtn .toyama {
	top: 46.6%;
    left: 72.1%;
}
.healthcare_facility .map .tabBtn .ishikawa {
	top: 46.6%;
    left: 65.9%;
}
.healthcare_facility .map .tabBtn .fukui {
	top: 54.8%;
    left: 59.7%;
}
.healthcare_facility .map .tabBtn .gifu {
	top: 54.8%;
    left: 65.9%;
}
.healthcare_facility .map .tabBtn .shizuoka {
	top: 63.1%;
    left: 65.9%;
}
.healthcare_facility .map .tabBtn .aichi {
	top: 63.1%;
    left: 59.7%;
}
.healthcare_facility .map .tabBtn .mie {
	top: 63.1%;
    left: 53.6%;
}
.healthcare_facility .map .tabBtn .shiga {
	top: 54.8%;
    left: 53.6%;
}
.healthcare_facility .map .tabBtn .kyoto {
	top: 54.8%;
    left: 47.4%;
}
.healthcare_facility .map .tabBtn .osaka {
	top: 63.1%;
    left: 41.2%;
}
.healthcare_facility .map .tabBtn .hyogo {
	top: 54.8%;
    left: 41.2%;
}
.healthcare_facility .map .tabBtn .nara {
	top: 63.1%;
    left: 47.4%;
}
.healthcare_facility .map .tabBtn .wakayama {
	top: 71.3%;
    left: 47.4%;
}
.healthcare_facility .map .tabBtn .tottori {
	top: 54.8%;
    left: 35%;
}
.healthcare_facility .map .tabBtn .shimane {
	top: 54.8%;
    left: 28.8%;
}
.healthcare_facility .map .tabBtn .okayama {
	top: 63.1%;
    left: 35%;
}
.healthcare_facility .map .tabBtn .hiroshima {
	top: 63.1%;
    left: 28.8%;
}
.healthcare_facility .map .tabBtn .yamaguchi {
	top: 63.1%;
    left: 22.7%;
}
.healthcare_facility .map .tabBtn .tokushima {
	top: 79.6%;
    left: 35%;
}
.healthcare_facility .map .tabBtn .kagawa {
	top: 71.3%;
    left: 35%;
}
.healthcare_facility .map .tabBtn .ehime {
	top: 71.3%;
    left: 28.8%;
}
.healthcare_facility .map .tabBtn .kochi {
	top: 79.6%;
    left: 28.8%;
}
.healthcare_facility .map .tabBtn .fukuoka {
	top: 63.1%;
    left: 16.5%;
}
.healthcare_facility .map .tabBtn .saga {
	top: 63.1%;
    left: 10.3%;
}
.healthcare_facility .map .tabBtn .nagasaki {
	top: 63.1%;
    left: 4.1%;
}
.healthcare_facility .map .tabBtn .kumamoto {
	top: 71.3%;
    left: 10.3%;
}
.healthcare_facility .map .tabBtn .oita {
	top: 71.3%;
    left: 16.5%;
}
.healthcare_facility .map .tabBtn .miyazaki {
	top: 79.6%;
    left: 16.5%;
}
.healthcare_facility .map .tabBtn .kagoshima {
	top: 79.6%;
    left: 10.3%;
}
.healthcare_facility .map .tabBtn .okinawa {
	top: 87.9%;
    left: 4.1%;
}
.healthcare_facility .map .tabBtn .item.url_none {
	opacity: 1;
	background: rgb(100,100,100,0.4);
}

/*
 * お問い合わせ contact
*/

.contact {

}
.contact .content_header{
	background-image:url(../images/low/bg_hd_faq.png);
}
.contact .hd_text {
	background: #B5DEA0;
	background: linear-gradient(90deg,rgba(181, 222, 160, 1) 0%, rgba(120, 191, 103, 1) 100%);
}
.contact h3 span::before {
	background-color:#CCE0BD;
}

.contact .content p.center {
	
}
.contact .form {
	
}

.contact .form dl {
	display: flex;
	font-size: 20px;
	padding: 20px 0;
	border-bottom: 1px solid #eee;
}
.contact .form dl dt {
	width: 30%;
}
.contact .form dl dt p{
	border-left: solid 10px #429A3E;
	padding-left:5px;
	padding-top:3px;
	padding-bottom:3px;
}
.contact .form dl dt sup {
	font-size: 0.7em;
	color: red;
	vertical-align: top;
}
.contact .form dl dd {
	width: 60%;
}
.contact .form dl dd input {
	padding: 3px;
	font-size: 16px;
	width: 100%;
}
.contact .form dl dd textarea {
	padding: 3px;
	font-size: 16px;
	width: 100%;
}
.contact input[type="submit"] {
	appearance: none;
	-webkit-appearance: none;
	-moz-appearance: none;
	font-size: 20px;
	font-weight: bold;
	width: 200px;
	padding: 10px;
	border-radius: 10px;
	background-color: #429A3E;
	border: solid 1px #429A3E;
	color: #fff;
	cursor: pointer;
	transition: transform 0.3s ease;
}
.contact input[type="submit"]:hover {
	background-color: #fff;
	color: #429A3E;
}
.contact span.wpcf7-spinner {
  display: none;
}
.contact .submit {
	text-align: center;
	
}
.contact .submit p {
	font-size: 20px;
}
/*
 * お知らせ single
*/
.single .hd_text {
	background: #B5DEA0;
	background: linear-gradient(90deg,rgba(181, 222, 160, 1) 0%, rgba(120, 191, 103, 1) 100%);
}
.single h3 span::before {
	background-color:#CCE0BD;
}



@media screen and (max-width: 999px) {
	main {
		padding: 0 10px;
	}
	.about .introduction > p {
		padding: 0 3rem 2rem;
	}
	.about .introduction .notes {
		padding: 2rem 3rem 2rem;
	}
	.about .annotation {
		margin: 2rem 3rem;
	}
	.introduction h2 {
		font-size: 26px;
	}
	.introduction .research .text {
		font-size: 22px;
	}
	.member_wrap {
		flex-flow:column;
	}
	.member .member_wrap > div {
		width:330px;
		margin-bottom:200px;
	}
	.member .member_wrap > div:last-child {
		margin-bottom:30px;
	}
	.clinical-trial .flex_box {
		flex-flow:column;
		align-items:center;
	}
	.clinical-trial .flex_box .clinical {
		margin-bottom:30px;
	}
}
@media screen and (max-width: 750px) {
	h4 {
		line-height:1.5;
	}
	.healthcare_facility .map {
		padding: 30px
	}
	.healthcare_facility .map img {
		display: none;
	}
	.healthcare_facility .map .tabBtn {
       display: -webkit-box;
        display: -ms-flexbox;
        display: flex;
        -ms-flex-wrap: wrap;
        flex-wrap: wrap;
        padding: 0 4vw;
        position: static;
		font-size: 16px;
    }
	.healthcare_facility .map .tabBtn .item {
		display: -webkit-box;
        display: -ms-flexbox;
        display: flex;
        -webkit-box-align: center;
        -ms-flex-align: center;
        align-items: center;
        -webkit-box-pack: center;
        -ms-flex-pack: center;
        justify-content: center;
        width: calc((100% - 10px* 5) / 6);
        height: 30px;
        font-size: 14px;
        color: #fff;
        text-indent: 0;
        margin-right: 10px;
        position: static;
        opacity: 1;
	}
	.healthcare_facility .map .tabBtn .item:nth-child(n+6) {
		margin-top: 10px;
	}
	.healthcare_facility .map .tabBtn .hokkaido {
		background: #5691e3;
	}
	.healthcare_facility .map .tabBtn .aomori,.healthcare_facility .map .tabBtn .iwate,.healthcare_facility .map .tabBtn .miyagi,.healthcare_facility .map .tabBtn .akita,.healthcare_facility .map .tabBtn .yamagata,.healthcare_facility .map .tabBtn .fukushima {
		background: #7aa2e2;
	}
	.healthcare_facility .map .tabBtn .ibaraki,.healthcare_facility .map .tabBtn .tochigi,.healthcare_facility .map .tabBtn .gunma,.healthcare_facility .map .tabBtn .saitama,.healthcare_facility .map .tabBtn .chiba,.healthcare_facility .map .tabBtn .tokyo,.healthcare_facility .map .tabBtn .kanagawa {
		background: #5faaaa;
	}
	.healthcare_facility .map .tabBtn .yamanashi,.healthcare_facility .map .tabBtn .nagano,.healthcare_facility .map .tabBtn .niigata,.healthcare_facility .map .tabBtn .toyama,.healthcare_facility .map .tabBtn .ishikawa,.healthcare_facility .map .tabBtn .fukui,.healthcare_facility .map .tabBtn .gifu,.healthcare_facility .map .tabBtn .shizuoka,.healthcare_facility .map .tabBtn .aichi {
		background: #81ab64;
	}
	.healthcare_facility .map .tabBtn .mie,.healthcare_facility .map .tabBtn .shiga,.healthcare_facility .map .tabBtn .kyoto,.healthcare_facility .map .tabBtn .osaka,.healthcare_facility .map .tabBtn .hyogo,.healthcare_facility .map .tabBtn .nara,.healthcare_facility .map .tabBtn .wakayama {
		background: #a483bc;
	}
	.healthcare_facility .map .tabBtn .tottori,.healthcare_facility .map .tabBtn .shimane,.healthcare_facility .map .tabBtn .okayama,.healthcare_facility .map .tabBtn .hiroshima,.healthcare_facility .map .tabBtn .yamaguchi {
		background: #c8769e;
	}
	.healthcare_facility .map .tabBtn .tokushima,.healthcare_facility .map .tabBtn .kagawa,.healthcare_facility .map .tabBtn .ehime,.healthcare_facility .map .tabBtn .kochi {
		background: #ce9f52;
	}
	.healthcare_facility .map .tabBtn .fukuoka,.healthcare_facility .map .tabBtn .saga,.healthcare_facility .map .tabBtn .nagasaki,.healthcare_facility .map .tabBtn .kumamoto,.healthcare_facility .map .tabBtn .oita,.healthcare_facility .map .tabBtn .miyazaki,.healthcare_facility .map .tabBtn .kagoshima,.healthcare_facility .map .tabBtn .okinawa {
		background: #d06667;
	}
	.contact .form dl {
		flex-flow: column;
	}
	.contact .form dl dt {
		width: 100%;
		margin-bottom: 10px;
	}
	.contact .form dl dd {
		width: 100%;
	}
	.diagnosis .flex_box .url a {
		padding: 0.5rem 1rem;
	}
	.research .purpose .flex_box {
		flex-flow:column;
	}
	.research .purpose .flex_box > div {
		width:100%;
	}
	.research .purpose .flex_box .left_col {
		margin-bottom: 30px;
	}
	.research .overview dl {
		flex-flow:column;
	}
	.research .overview dl dt,.research .overview dl dd {
		width:100%;
	}
	.how-to-participate h3 span::before {
		background-color: #fff;
	}
	.how-to-participate .flex_box .submit_btn {
		width:100%;
	}
}
@media screen and (max-width: 680px) {
	.diagnosis .understanding h3 span, .diagnosis .practical h3 span {
		padding: 1rem;
	}
	.about .content {
		padding: 0 2rem 2rem;
	}
	    .about .annotation {
			margin: 2rem 2rem;
	}
	.introduction .purpose .flex_box {
		flex-flow: column;
	}
	.introduction .purpose .flex_box div {
		width: 100%;
	}
	.introduction h3 {
		text-align: center;
	}
	.introduction .purpose .bold {
		height: auto;
	}
	.introduction .purpose p {
		margin-bottom: 30px;
	}
	.introduction .overview dl {
		flex-flow: column;
	}
	.introduction .overview dl dt,.introduction .overview dl dd {
		width: 100%;
	}
	.introduction .schedule .content_wrap {
		padding: 50px 0;
	}
	.how-to-participate .facility_registration .flex_box {
		flex-flow: column;
	}
	.how-to-participate .facility_registration .flex_box > div {
		margin-bottom: 50px;
	}
	.how-to-participate .redcap_registration .flex_box {
		flex-flow: column;
	}
	.how-to-participate .redcap_flex .image {
		text-align: center;
		margin-top: 30px;
	}
	.how-to-participate .redcap_registration .flex_box .site_image {
		width: 100%;
	}
	.how-to-participate .redcap_registration .flex_box .redcap_url {
		width: 100%;
		margin-top: 30px;
	}
	.how-to-participate .redcap_registration .flex_box .irb {
		margin-top:30px;
		width:100%;
	}
	.how-to-participate .flex_box {
		flex-flow: column;
	}
	.how-to-participate .completion .submit_btn {
		width:100%;
	}
	.case-registration-site section {
		padding: 2rem;
	}
	.facilities .flex_box {
		flex-flow: column;
	}
	.facilities .flex_box div {
		width: 100%;
		margin-bottom: 50px;
	}
	.patient .flex_box {
		flex-flow: column;
		width: 100%;
	}
	.patient .flex_box .image {
		margin-top: 30px;
		width: 40%;
	}
	
	.diagnosis .flex_wrap {
		flex-flow: column;
	}
	.diagnosis .flex_wrap > div {
		width: 100%;
		margin-bottom: 50px;
	}
	.diagnosis .practical .flex_box {
		flex-flow: column;
	}
	.diagnosis .flex_box .image, .diagnosis .flex_box .text {
		width: 100%;
	}
	.diagnosis .flex_box .url {
		width: 100%;
		margin-top: 30px;
	}
	.diagnosis .understanding .left_col {
		border-right:none;
	}
	.diagnosis .practical {
		padding: 50px 2rem;
	}
	.member .member_list p {
		margin-bottom:10px;
	}
	.flow-of-registration .submit {
		width:100%;
	}
	.case-registration-site .submit_area {
		flex-flow: column;
	}
	.case-registration-site .submit_area .submit {
		width: 100%;
		margin-bottom: 30px;
	}
	.healthcare_facility h3 span::before,.contact h3 span::before {
		background-color:#fff;
	}
}
@media screen and (max-width: 480px) {
	.diagnosis .practical {
		padding: 50px 1rem;
	}
	.diagnosis .diagnosed p.text {
		padding-left: 0;
	}
	.diagnosis .flex_box .url a {
		font-size:14px;
	}
	.clinical-trial .flex_box > div {
		width:100%;
		background-size:contain;
		background-position: center center;
		aspect-ratio: 420 / 300;
	}
	.clinical-trial .flex_box .background {
		width:100%;
	}
	.healthcare_facility .content {
		padding:0;
	}
	.healthcare_facility .map {
		padding:20px 0;
	}
}